The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 147, 605-610, Copyright © 1978 by Rockefeller University Press

ARTICLES

Antibody-dependent cellular cytotoxicity by allosensitized human T cells

RL Evans, L Chess, H Levine and SF Schlossman

Peripheral human T cells, isolated by sheep erythrocyte-rosette formation and density centrifugation, were highly cytotoxic to both Ab- coated autologous lymphocytes and antibody (Ab)-coated chicken erythrocytes when stimulated in mixed lymphocyte culture, but were not lytic when freshly purified, or when unstimulated in 6-day culture. Allosensitized T cells were shown to effect this activity by a specific effector-target cell interaction dependent on Ab, as indicated by: (a) induction of killing by Ab to target cells not lysed in the absence of Ab. (b) inhibition of Ab-dependent killing by aggregated Ig. The mechanism by which allosensitized T cells effect antibody-dependent cellular cytotoxicity is discussed.
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