The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 146, 1549-1560, Copyright © 1977 by Rockefeller University Press

ARTICLES

Immunochemical evidence for three Ia loci in the I-region of the H-2 complex

TL Delovitch, DB Murphy and HO McDevitt

Sequential immunoprecipitation analyses of Ia antigens were performed with 125I-labeled B10, B10.A(3R), and B10.A(5R) spleen cell lysates. The results suggest the presence of one I-region associated (Ia) locus (Ia-1) in the I-A subregion. In addition, they indicate that two Ia loci map between the I-J and S regions. One locus, Ia-5, maps in the I- E subregion. The second locus, most likely Ia-3, maps in either the I-E or I-C subregion. Taken together, the data demonstrate that at least three Ia loci in the I-region of the H-2 complex code for molecules detectable by immunoprecipitation.
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