The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 146, 881-886, Copyright © 1977 by Rockefeller University Press

ARTICLES

Release from maternally-induced allotypic suppression in rabbit by Nocardia water-soluble mitogen

C Bona and PA Cazenave

The in vitro synthesis of allotypes of b4/b5 offspring obtained from b4/b4 mothers immunized against paternal allotype b5/b5 was studied in comparison to similar offspring that had escaped from suppression and normal heterozygous b4/b5 rabbits. Nocardia water-soluble mitogen-a rabbit B-cell mitogen which is known to induce the differentiation of small lymphocytes into plasma cells and polyclonal activation of Ig, was able to break in vitro the allotypic suppression induced in vivo.
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