Biosynthesis of pro-C3, a precursor of the third component of complement

doi:10.1084/jem.146.3.759

This Article

	Full Text (PDF, 526K)
	Alert me when this article is cited

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Brade, V.
	Articles by Colten, H. R.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Brade, V.
	Articles by Colten, H. R.


Social Bookmarking

	What's this?

ARTICLES

Biosynthesis of pro-C3, a precursor of the third component of complement

V Brade, RE Hall and HR Colten

A precusor of the third component of complement, pro-C3, was detected in studies of cell-free synthesis and intracellularly in homogenates of liver tissue cultures. The molecular weight of pro-C3 was indistinguishable from that of intact native C3 secreted in vitro by liver or peritoneal macrophages, but its structure was different. Pro- C3 is a single polypeptide chain, whereas C3 secreted by cells in culture consists of two polypeptide chains (mol wt 120,000 and 76,000) linked by disulfide bonds.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Morris, K., Goldberger, G, Colten, H., Aden, D., Knowles, B. (1982). Biosynthesis and processing of a human precursor complement protein, pro-C3, in a hepatoma-derived cell line. Science 215: 399-400 [Abstract]