The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 146, 368-380, Copyright © 1977 by Rockefeller University Press

ARTICLES

A suppressor T cell in the human mixed lymphocyte reaction

AJ McMichael and T Sasazuki

Lymphocytes from an HLA-B7 DW2 homozygous multiparous woman, J.H., failed to respond in the mixed lymphocyte reaction to lymphocytes from her DW1 homozygous husband, W.H., and certain other homozygous typing cells. J.H. lymphocytes could suppress the response of HLA matched responders to W.H. This effect was shown to be radiosensitive and due to a T cell. The suppressor cell showed antigen specificity.
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