Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG

doi:10.1084/jem.146.1.184

This Article

Full Text (PDF, 1004K)

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JEM

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Moretta, L.

Articles by Cooper, M. D.

Search for Related Content

PubMed

PubMed Citation

Articles by Moretta, L.

Articles by Cooper, M. D.

Pubmed/NCBI databases

Substance via MeSH

Social Bookmarking

What's this?

ARTICLES

Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG

L Moretta, SR Webb, CE Grossi, PM Lydyard and MD Cooper

Subpopulations of thymus-derived T lymphocytes bearing receptors for either IgM or IgG molecules were isolated from human peripheral blood. Those with receptors for IgM (T.M) provided help in a cell dose- dependent fashion for the pokeweed mitogen-induced differentiation of B lymphocytes in vitro, whereas cells with receptors for IgG (T.G) did not. T.G cells, on the hand, efficiently suppressed the differentiation and proliferation of B cells in the pokeweed system in the presence of helper T.M cells. This suppressive activity of T.G cells required prior interaction of the T.G cells with immune complexes. The helper activity of T.M cells was relatively radioresistant while the suppressor activity of T.G cells was radiosensitive. The results indicate that helper and suppressor functions of human T lymphocytes in this model system are mediated by different subpopulations of T cells which can be distinguished by their ability to bind IgM or IgG immune complexes, respectively.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Kubagawa, H., Oka, S., Kubagawa, Y., Torii, I., Takayama, E., Kang, D.-W., Gartland, G. L., Bertoli, L. F., Mori, H., Takatsu, H., Kitamura, T., Ohno, H., Wang, J.-Y. (2009). Identity of the elusive IgM Fc receptor (Fc{micro}R) in humans. JEM 206: 2779-2793 [Abstract] [Full Text]
Clemenceau, B., Vivien, R., Berthome, M., Robillard, N., Garand, R., Gallot, G., Vollant, S., Vie, H. (2008). Effector Memory {alpha}{beta} T Lymphocytes Can Express Fc{gamma}RIIIa and Mediate Antibody-Dependent Cellular Cytotoxicity. J. Immunol. 180: 5327-5334 [Abstract] [Full Text]
Moreno-Altamirano, M. M. B., Sanchez-Garcia, F. J., Munoz, M. L. (2002). Non Fc receptor-mediated infection of human macrophages by dengue virus serotype 2. J. Gen. Virol. 83: 1123-1130 [Abstract] [Full Text]
Ogle, C. K., Ogle, J. D., Alexander, J. W. (1989). Review: The Basics of Immunological Tests. JPEN J Parenter Enteral Nutr 13: 651-657 [Abstract]
TORRE, D., MAGGIOLO, F., SAMPIETRO, C., INGROSSO, G., Issi, M., Rossi, D. (1986). Lymphocyte Subpopulations and Corticosteroid Treatment in Patients With Pertussis. Arch Pediatr Adolesc Med 140: 1094-1094 [Abstract]
DECKER, J. L., MALONE, D. G., HARAOUI, B., WAHL, S. M., SCHRIEBER, L., KLIPPEL, J. H., STEINBERG, A. D., WILDER, R. L. (1984). Rheumatoid Arthritis: Evolving Concepts of Pathogenesis and Treatment. ANN INTERN MED 101: 810-824 [Abstract]
Fuerst, D. J., Tessler, H. H., Fishman, G. A., Yokoyama, M. M., Wyhinny, G. J., Vygantas, C. M. (1984). Birdshot Retinochoroidopathy. Arch Ophthalmol 102: 214-219 [Abstract]
FAUCI, A. S., LANE, H. C., VOLKMAN, D. J. (1983). Activation and Regulation of Human Immune Responses: Implications in Normal and Disease States. ANN INTERN MED 99: 61-75 [Abstract]
SOLOMON, G., BARLAND, P., RIFKIN, H. (1982). Eosinophilic Fasciitis Responsive to Cimetidine. ANN INTERN MED 97: 547-549 [Abstract]
ALLEN, J. I., KAY, N. E., McCLAIN, C. J. (1981). Severe Zinc Deficiency in Humans: Association with a Reversible T-Lymphocyte Dysfunction. ANN INTERN MED 95: 154-157 [Abstract]
DANIELE, R. P., DAUBER, J. H., ROSSMAN, M. D. (1980). Immunologic Abnormalities in Sarcoidosis. ANN INTERN MED 92: 406-416 [Abstract]
MOUTSOPOULOS, H. M., CHUSED, T. M., MANN, D. L., KLIPPEL, J. H., FAUCI, A. S., FRANK, M. M., LAWLEY, T. J., HAMBURGER, M. I. (1980). Sjogren's Syndrome (Sicca Syndrome): Current Issues. ANN INTERN MED 92: 212-226 [Abstract]
ALLERGY AND IMMUNOLOGY COMMITTEE, (1979). Allergy and Immunology: An Annotated Bibliography of Recent Literature: References to Journal Articles and Other Papers. ANN INTERN MED 90: 135-139 [Abstract]