The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 145, 1607-1611, Copyright © 1977 by Rockefeller University Press

ARTICLES

On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain

JA Cohn, AP Alvares and A Kappas

The difference spectra of the carbon monoxide-complex of dithionite- reduced rat brain microsomes, compared with both reduced microsomes, alone, and the carbon monoxide-complex of oxidized microsomes, indicate the presence of small amounts of cytochrome P-450 in brain. As in liver, cytochrome P-450 in brain is degraded in vitro to its inactive form, cytochrome P-420 by methylmercury chloride. Aryl hydrocarbon hydroxylase activity is also present in rat brain microsomes and, at lower specific activity, in brain homogenates. This carcinogen metabolizing activity is increased four-fold in rats pretreated with 3- methylcholanthrene.
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