Journal of Experimental Medicine, Vol 145, 1559-1566, Copyright © 1977 by Rockefeller University Press
Presence on idiotype-specific suppressor T cells of receptors that interact with molecules bearing the idiotype
FL Owen, ST Ju and A Nisonoff
All A/J mice produce anti-p-azophenylarsonate (anti-Ar) antibodies, some of
which share a cross-reactive idiotype. The idiotype can be suppressed by
treatment with anti-idiotypic antiserum before immunization, although
normal concentrations of anti-Ar antibodies are synthesized. We have
previously reported that such suppressed mice, if hyperimmunized and then
allowed to rest, contain up to 10% of splenic T cells which form rosettes
with autologous RBC coated with Fab fragments of anti-Ar antibodies bearing
the idiotype. Our present results indicate that the rosette-forming T cells
include the idiotype-specific suppressor T-cell population. The suppressive
activity is largely depleted by removal of the rosette-forming lymphocytes,
and the rosettes themselves are highly suppressive. The data do not
establish whether all of the idiotype-specific rosette-forming cells are
suppressor cells. The system may provide a source of large numbers of
suppressor cells for further study, and facilitate investigation of the
mechanism of generation of idiotype-specific suppressor cells.
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