The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 145, 1077-1081, Copyright © 1977 by Rockefeller University Press

ARTICLES

Immune mechanisms in leukemia role of the Ia antigens

OA Lukasewycz and JA Frelinger

We have shown that the selective removal of cells possessing Ia determinants coded by the I-A, I-B, and I-J regions of the H-2 gene complex completely abrogates the protective capacity of nylon-wool- purified T lymphocytes against leukemic challenge. This suggests that the Ia antigen bearing T cells play an important role in tumor immunity.
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