The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 145, 607-617, Copyright © 1977 by Rockefeller University Press

ARTICLES

Differences in pyrogen production by mononuclear phagocytes and by fibroblasts or HeLa cells

P Bodel and H Miller
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510.

Phagocytosis of bacteria stimulates "professional" phagocytes to produce and release endogenous pyrogen (EP), the protein that mediates fever. To determine whether "nonprofessional" phagocytes also have this capacity, mouse and human fibroblasts and HeLa cells were cultured after ingestion of latex or chicken erythrocytes (CE), and EP release into culture supernate measured by mouse assay. No detectable pyrogen was released by these cell types after phagocytosis, whereas both latex and CE stimulated EP production by cultured mouse macrophages. These studies support the hypothesis that only professional phagocytes of bone marrow origin synthesize EP and induce fever.
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