The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 145, 466-471, Copyright © 1977 by Rockefeller University Press

ARTICLES

Thymus-like activities of sulphur derivatives on T-cell differentiation

G Renoux and M Renoux

Levamisole and sodium diethyldithiocarbamate can induce in vivo thymocyte differentiation from precursor spleen cells of nu/nu mice and evoke indirect plaque-forming cells in nude mice immunized with sheep red cells. These sulphur drugs induce in thymusless mice the production of a serum factor which transfer in vivo immune enhancement and in vitro thymocyte differentiation. In vivo treatment with sulphur derivative can substitute for an alleged thymice hormone.
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