Journal of Experimental Medicine, Vol 144, 1689-1694, Copyright © 1976 by Rockefeller University Press

ARTICLES

Macrophage plasminogen activator: induction by asbestos is blocked by anti-inflammatory steroids

J Hamilton, JD Vassalli and E Reich

Intraperitoneal injection of asbestos fibres into mice induces the formation of exudates containing macrophages that produce plasminogen activator. Like-wise, in vitro addition of asbestos to macrophage cultures stimulates plasminogen activator secretion; the synthesis and secretion of lysozyme and lysosomal enzymes are not changed under these conditions. The enhanced secretion of plasminogen activator by macrophages exposed to asbestos is suppressed by low concentrations of anti-inflammatory steroids.
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This article has been cited by other articles:

• Davies, R., Rifkin, D., Tepper, R, Miller, A, Kucherlapati, R (1983). A polypeptide secreted by transformed cells that modulates human plasminogen activator production. Science 221: 171-173 [Abstract]  
• Mangel, W. F., Livingston, D. C., Brocklehurst, J. R., Liu, H.-Y., Peltz, G. A., Cannon, J. F., Leytus, S. P., Wehrly, J. A., Salter, B. L., Mosher, J. L. (1980). New Assay for the Plasminogen Activator Activity of Transformed Cells. Cold Spring Harb Symp Quant Biol 44: 669-680 [Abstract]  

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