Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection

doi:10.1084/jem.144.5.1305

This Article

	Full Text (PDF, 664K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Gresser, I.
	Articles by Brouty-Boye, D.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Gresser, I.
	Articles by Brouty-Boye, D.


Social Bookmarking

	What's this?

ARTICLES

Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection

I Gresser, MG Tovey, ME Bandu, C Maury and D Brouty-Boye

The role of interferon in the pathogenesis of encephalomyocarditis (EMC) virus infection was determined by treating mice with potent, partially purified sheep anti-mouse interferon globulin. In control mice, EMC virus was present in low titers in various visceral organs but attained high titers in the brain towards the 4th to 5th day, at which time mice died with signs of central nervous system disease. In mice treated with anti-mouse interferon globulin, virus was present in high titer in visceral organs 24--36 h after viral inoculation and virtually all mice were dead by 45 h. This rapid evolution of EMC virus infection was not observed in mice treated with the globulin fraction prepared from a normal sheep, from a sheep exhibiting a low anti-mouse interferon-neutralizing titer, nor from a sheep having a high titer of antibody to human leukocyte interferon. The experimental results indicated that anti-interferon globulin neutralized the interferon liberated by virus-infected cells, thus permitting extensive virus multiplication in several visceral organs. We conclude that interferon is an important early component of host resistance to this virus infection.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Ngoi, S. M., Tovey, M. G., Vella, A. T. (2008). Targeting Poly(I:C) to the TLR3-Independent Pathway Boosts Effector CD8 T Cell Differentiation through IFN-{alpha}/{beta}. J. Immunol. 181: 7670-7680 [Abstract] [Full Text]
Currie, A. J., van der Most, R. G., Broomfield, S. A., Prosser, A. C., Tovey, M. G., Robinson, B. W. S. (2008). Targeting the Effector Site with IFN-{alpha}{beta}-Inducing TLR Ligands Reactivates Tumor-Resident CD8 T Cell Responses to Eradicate Established Solid Tumors. J. Immunol. 180: 1535-1544 [Abstract] [Full Text]
Hosmalin, A., Lebon, P. (2006). Type I interferon production in HIV-infected patients. J. Leukoc. Biol. 80: 984-993 [Abstract] [Full Text]
Costa, V. M. A., Torres, K. C. L., Mendonca, R. Z., Gresser, I., Gollob, K. J., Abrahamsohn, I. A. (2006). Type I IFNs Stimulate Nitric Oxide Production and Resistance to Trypanosoma cruzi Infection.. J. Immunol. 177: 3193-3200 [Abstract] [Full Text]
Barton, E. S., Lutzke, M. L., Rochford, R., Virgin, H. W. IV (2005). Alpha/Beta Interferons Regulate Murine Gammaherpesvirus Latent Gene Expression and Reactivation from Latency. J. Virol. 79: 14149-14160 [Abstract] [Full Text]
Schiavoni, G., Mauri, C., Carlei, D., Belardelli, F., Castellani Pastoris, M., Proietti, E. (2004). Type I IFN Protects Permissive Macrophages from Legionella pneumophila Infection through an IFN-{gamma}-Independent Pathway. J. Immunol. 173: 1266-1275 [Abstract] [Full Text]
Crow, Y J, Black, D N, Ali, M, Bond, J, Jackson, A P, Lefson, M, Michaud, J, Roberts, E, Stephenson, J B P, Woods, C G, Lebon, P (2003). Cree encephalitis is allelic with Aicardi-Goutieres syndrome: implications for the pathogenesis of disorders of interferon alpha metabolism. J. Med. Genet. 40: 183-187 [Abstract] [Full Text]
Wieland, S. F., Vega, R. G., Muller, R., Evans, C. F., Hilbush, B., Guidotti, L. G., Sutcliffe, J. G., Schultz, P. G., Chisari, F. V. (2002). Searching for Interferon-Induced Genes That Inhibit Hepatitis B Virus Replication in Transgenic Mouse Hepatocytes. J. Virol. 77: 1227-1236 [Abstract] [Full Text]
Montoya, M., Schiavoni, G., Mattei, F., Gresser, I., Belardelli, F., Borrow, P., Tough, D. F. (2002). Type I interferons produced by dendritic cells promote their phenotypic and functional activation. Blood 99: 3263-3271 [Abstract] [Full Text]
Eberl, G., Brawand, P., MacDonald, H. R. (2000). Selective Bystander Proliferation of Memory CD4+ and CD8+ T Cells Upon NK T or T Cell Activation. J. Immunol. 165: 4305-4311 [Abstract] [Full Text]
Schiavoni, G., Mattei, F., Di Pucchio, T., Santini, S. M., Bracci, L., Belardelli, F., Proietti, E. (2000). Cyclophosphamide induces type I interferon and augments the number of CD44hi T lymphocytes in mice: implications for strategies of chemoimmunotherapy of cancer. Blood 95: 2024-2030 [Abstract] [Full Text]
Hiroishi, K., Tuting, T., Lotze, M. T. (2000). IFN-{alpha}-Expressing Tumor Cells Enhance Generation and Promote Survival of Tumor-Specific CTLs. J. Immunol. 164: 567-572 [Abstract] [Full Text]
Hefti, H. P., Frese, M., Landis, H., Di Paolo, C., Aguzzi, A., Haller, O., Pavlovic, J. (1999). Human MxA Protein Protects Mice Lacking a Functional Alpha/Beta Interferon System against La Crosse Virus and Other Lethal Viral Infections. J. Virol. 73: 6984-6991 [Abstract] [Full Text]
Cavanaugh, V. J., Guidotti, L. G., Chisari, F. V. (1998). Inhibition of Hepatitis B Virus Replication during Adenovirus and Cytomegalovirus Infections in Transgenic Mice. J. Virol. 72: 2630-2637 [Abstract] [Full Text]
Yamamoto, N., Shibamori, M., Ogura, M., Seko, Y., Kikuchi, M. (1998). Effects of Intranasal Administration of Recombinant Murine Interferon-{gamma} on Murine Acute Myocarditis Caused by Encephalomyocarditis Virus. Circulation 97: 1017-1023 [Abstract] [Full Text]
Cousens, L.�P., Orange, J.�S., Su, H.�C., Biron, C.�A. (1997). Interferon-alpha /beta inhibition of interleukin 12�and interferon-gamma production in vitro and endogenously during viral infection. Proc. Natl. Acad. Sci. USA 94: 634-639 [Abstract] [Full Text]
Muller, U, Steinhoff, U, Reis, L., Hemmi, S, Pavlovic, J, Zinkernagel, R., Aguet, M (1994). Functional role of type I and type II interferons in antiviral defense. Science 264: 1918-1921 [Abstract]
STIEHM, E. R., KRONENBERG, L. H., ROSENBLATT, H. M., BRYSON, Y., MERIGAN, T. C. (1982). Interferon: Immunobiology and Clinical Significance. ANN INTERN MED 96: 80-93 [Abstract]