The Journal of Experimental Medicine
VeriKine-HS Human IFN-Beta
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*NITROPHENOLS
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Journal of Experimental Medicine, Vol 144, 1134-1140, Copyright © 1976 by Rockefeller University Press

ARTICLES

Cell-mediated lympholysis to H-2-matched target cells modified with a series of nitrophenyl compounds

TG Rehn, JK Inman and GM Shearer

The specificity of C57BL/10 cytotoxic effector cells generated by in vitro sensitization with autologous spleen cells modified with a series of related nitrophenyl compounds was investigated. The failure of trinitrophenyl (TNP)-sensitized effector cells to lyse TNP-beta- alanylglycylglycyl(AGG)-modified target cells is presented as evidence contradicting the intimacy or dual receptor model or T-cell recognition in its simplest form. Data are also shown indicating that sensitization with N-(3-nitro-4-hydroxy-5-iodophenylacetyl)-AGG-modified stimulating cells generates noncross-reacting clones of cytotoxic effector cells.
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