Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules

doi:10.1084/jem.144.3.828

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Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules

HB Stamper Jr and JJ Woodruff

An in vitro model is described for studying the interaction between lymphocytes and high-endothelial venules (HEV) of lymph nodes. Rat or mouse lymphocytes which were layered over fixed sections of syngeneic lymph nodes adhered selectively to the endothelium of HEV but did not bind to other vascular endothelia. Evidence is presented that adherence to HEV in vitro is a property of recirculating lymphocytes and not a characteristic of cells which are unable to home into lymph nodes in vivo.
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Uchimura, K., Kadomatsu, K., El-Fasakhany, F. M., Singer, M. S., Izawa, M., Kannagi, R., Takeda, N., Rosen, S. D., Muramatsu, T. (2004). N-Acetylglucosamine 6-O-Sulfotransferase-1 Regulates Expression of L-Selectin Ligands and Lymphocyte Homing. J. Biol. Chem. 279: 35001-35008 [Abstract] [Full Text]
Katakai, T., Hara, T., Lee, J.-H., Gonda, H., Sugai, M., Shimizu, A. (2004). A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells. Int Immunol 16: 1133-1142 [Abstract] [Full Text]
Shintani, Y., Higashiyama, S., Ohta, M., Hirabayashi, H., Yamamoto, S., Yoshimasu, T., Matsuda, H., Matsuura, N. (2004). Overexpression of ADAM9 in Non-Small Cell Lung Cancer Correlates with Brain Metastasis. Cancer Res. 64: 4190-4196 [Abstract] [Full Text]
Hafezi-Moghadam, A., Thomas, K. L., Cornelssen, C. (2004). A novel mouse-driven ex vivo flow chamber for the study of leukocyte and platelet function. Am. J. Physiol. Cell Physiol. 286: C876-C892 [Abstract] [Full Text]
Milinkovic, M., Antin, J. H., Hergrueter, C. A., Underhill, C. B., Sackstein, R. (2004). CD44-hyaluronic acid interactions mediate shear-resistant binding of lymphocytes to dermal endothelium in acute cutaneous GVHD. Blood 103: 740-742 [Abstract] [Full Text]
Thatte, J., Dabak, V., Williams, M. B., Braciale, T. J., Ley, K. (2003). LFA-1 is required for retention of effector CD8 T cells in mouse lungs. Blood 101: 4916-4922 [Abstract] [Full Text]
Genbacev, O. D., Prakobphol, A., Foulk, R. A., Krtolica, A. R., Ilic, D., Singer, M. S., Yang, Z.-Q., Kiessling, L. L., Rosen, S. D., Fisher, S. J. (2003). Trophoblast L-Selectin-Mediated Adhesion at the Maternal-Fetal Interface. Science 299: 405-408 [Abstract] [Full Text]
Sackstein, R., Messina, J. L., Elfenbein, G. J. (2003). In vitro adherence of lymphocytes to dermal endothelium under shear stress: implications in pathobiology and steroid therapy of acute cutaneous GVHD. Blood 101: 771-778 [Abstract] [Full Text]
Fuhlbrigge, R. C., King, S. L., Dimitroff, C. J., Kupper, T. S., Sackstein, R. (2002). Direct Real-Time Observation of E- and P-Selectin-Mediated Rolling on Cutaneous Lymphocyte-Associated Antigen Immobilized on Western Blots. J. Immunol. 168: 5645-5651 [Abstract] [Full Text]
Forte, P., Pazmany, L., Matter-Reissmann, U. B., Stussi, G., Schneider, M. K. J., Seebach, J. D. (2001). HLA-G Inhibits Rolling Adhesion of Activated Human NK Cells on Porcine Endothelial Cells. J. Immunol. 167: 6002-6008 [Abstract] [Full Text]
Janatpour, M. J., Hudak, S., Sathe, M., Sedgwick, J. D., McEvoy, L. M. (2001). Tumor Necrosis Factor-dependent Segmental Control of MIG Expression by High Endothelial Venules in Inflamed Lymph Nodes Regulates Monocyte Recruitment. JEM 194: 1375-1384 [Abstract] [Full Text]
Irjala, H., Salmi, M., Alanen, K., Grenman, R., Jalkanen, S. (2001). Vascular Adhesion Protein 1 Mediates Binding of Immunotherapeutic Effector Cells to Tumor Endothelium. J. Immunol. 166: 6937-6943 [Abstract] [Full Text]
Sackstein, R., Dimitroff, C. J. (2000). A hematopoietic cell L-selectin ligand that is distinct from PSGL-1 and displays N-glycan-dependent binding activity. Blood 96: 2765-2774 [Abstract] [Full Text]
Ota, M., Takamura, N., Irimura, T. (2000). Involvement of Cell Surface Glycans in Adhesion of Human Colon Carcinoma Cells to Liver Tissue in a Frozen Section Assay: Role of Endo-{beta}-galactosidase-sensitive Structures. Cancer Res. 60: 5261-5268 [Abstract] [Full Text]
Jaakkola, K., Jalkanen, S., Kaunismaki, K., Vanttinen, E., Saukko, P., Alanen, K., Kallajoki, M., Voipio-Pulkki, L.-M., Salmi, M. (2000). Vascular adhesion protein-1, intercellular adhesion molecule-1 and P-Selectin mediate leukocyte binding to ischemic heart in humans. J Am Coll Cardiol 36: 122-129 [Abstract] [Full Text]
Salmi, M., Tohka, S., Jalkanen, S. (2000). Human Vascular Adhesion Protein-1 (VAP-1) Plays a Critical Role in Lymphocyte-Endothelial Cell Adhesion Cascade Under Shear. Circ. Res. 86: 1245-1251 [Abstract] [Full Text]
Csencsits, K. L., Jutila, M. A., Pascual, D. W. (1999). Nasal-Associated Lymphoid Tissue: Phenotypic and Functional Evidence for the Primary Role of Peripheral Node Addressin in Naive Lymphocyte Adhesion to High Endothelial Venules in a Mucosal Site. J. Immunol. 163: 1382-1389 [Abstract] [Full Text]
McNulty, C. A., Symon, F. A., Wardlaw, A. J. (1999). Characterization of the Integrin and Activation Steps Mediating Human Eosinophil and Neutrophil Adhesion to Chronically Inflamed Airway Endothelium. Am. J. Respir. Cell Mol. Bio. 20: 1251-1259 [Abstract] [Full Text]
Brodie, S. J., de la Rosa, C., Howe, J. G., Crouch, J., Travis, W. D., Diem, K. (1999). Pediatric AIDS-Associated Lymphocytic Interstitial Pneumonia and Pulmonary Arterio-Occlusive Disease : Role of VCAM-1/VLA-4 Adhesion Pathway and Human Herpesviruses. Am. J. Pathol. 154: 1453-1464 [Abstract] [Full Text]
Stupack, D. G., Li, E., Silletti, S. A., Kehler, J. A., Geahlen, R. L., Hahn, K., Nemerow, G. R., Cheresh, D. A. (1999). Matrix Valency Regulates Integrin-mediated Lymphoid Adhesion via Syk Kinase. JCB 144: 777-788 [Abstract] [Full Text]
Chakravorty, S. J., Howie, A. J., Cockwell, P., Adu, D., Savage, C. O. S. (1999). T Lymphocyte Adhesion Mechanisms within Inflamed Human Kidney : Studies with a Stamper-Woodruff Assay. Am. J. Pathol. 154: 503-514 [Abstract] [Full Text]
Tu, L., Delahunty, M. D., Ding, H., Luscinskas, F. W., Tedder, T. F. (1999). The Cutaneous Lymphocyte Antigen Is an Essential Component of the L-selectin Ligand Induced on Human Vascular Endothelial Cells. JEM 189: 241-252 [Abstract] [Full Text]
Constantin, G., Laudanna, C., Brocke, S., Butcher, E. C. (1999). Inhibition of Experimental Autoimmune Encephalomyelitis by a Tyrosine Kinase Inhibitor. J. Immunol. 162: 1144-1149 [Abstract] [Full Text]
Steeber, D. A., Tang, M. L. K., Zhang, X.-Q., Muller, W., Wagner, N., Tedder, T. F. (1998). Efficient Lymphocyte Migration Across High Endothelial Venules of Mouse Peyer's Patches Requires Overlapping Expression of L-Selectin and {beta}7 Integrin. J. Immunol. 161: 6638-6647 [Abstract] [Full Text]
Frey, M., Packianathan, N. B., Fehniger, T. A., Ross, M. E., Wang, W.-C., Stewart, C. C., Caligiuri, M. A., Evans, S. S. (1998). Differential Expression and Function of L-Selectin on CD56bright and CD56dim Natural Killer Cell Subsets. J. Immunol. 161: 400-408 [Abstract] [Full Text]
Tang, M. L. K., Steeber, D. A., Zhang, X.-Q., Tedder, T. F. (1998). Intrinsic Differences in L-Selectin Expression Levels Affect T and B Lymphocyte Subset-Specific Recirculation Pathways. J. Immunol. 160: 5113-5121 [Abstract] [Full Text]
Frohlich, D., Spertini, O., Moser, R. (1998). The Fcgamma Receptor-Mediated Respiratory Burst of Rolling Neutrophils to Cytokine-Activated, Immune Complex-Bearing Endothelial Cells Depends on L-Selectin But Not on E-Selectin. Blood 91: 2558-2564 [Abstract] [Full Text]
Clark, R. A., Fuhlbrigge, R. C., Springer, T. A. (1998). L-Selectin Ligands That Are O-glycoprotease Resistant and Distinct from MECA-79 Antigen are Sufficient for Tethering and Rolling of Lymphocytes on Human High Endothelial Venules. JCB 140: 721-731 [Abstract] [Full Text]
Wang, W.-C., Goldman, L. M., Schleider, D. M., Appenheimer, M. M., Subjeck, J. R., Repasky, E. A., Evans, S. S. (1998). Fever-Range Hyperthermia Enhances L-Selectin-Dependent Adhesion of Lymphocytes to Vascular Endothelium. J. Immunol. 160: 961-969 [Abstract] [Full Text]
Salmi, M., Tohka, S., Berg, E. L., Butcher, E. C., Jalkanen, S. (1997). Vascular Adhesion Protein 1 (VAP-1) Mediates Lymphocyte Subtype-specific, Selectin-independent Recognition of Vascular Endothelium in Human Lymph Nodes. JEM 186: 589-600 [Abstract] [Full Text]
Hanninen, A., Jaakkola, I., Salmi, M., Simell, O., Jalkanen, S. (1997). Ly-6C regulates endothelial adhesion and homing of CD8+ T cells by activating integrin-dependent�adhesion�pathways. Proc. Natl. Acad. Sci. USA 94: 6898-6903 [Abstract] [Full Text]
Sackstein, R., Fu, L., Allen, K. L. (1997). A Hematopoietic Cell L-Selectin Ligand Exhibits Sulfate-Independent Binding Activity. Blood 89: 2773-2781 [Abstract] [Full Text]
Catalina, M. D., Carroll, M. C., Arizpe, H., Takashima, A., Estess, P., Siegelman, M. H. (1996). The Route of Antigen Entry Determines the Requirement for L-selectin during Immune Responses. JEM 184: 2341-2352 [Abstract] [Full Text]
Masteller, E., Larsen, R., Carlson, L., Pickel, J., Nickoloff, B, Lowe, J, Thompson, C., Lee, K. (1995). Chicken B cells undergo discrete developmental changes in surface carbohydrate structure that appear to play a role in directing lymphocyte migration during embryogenesis. Development 121: 1657-1667 [Abstract]
Hourihan, H, Allen, T., Ager, A (1993). Lymphocyte migration across high endothelium is associated with increases in alpha 4 beta 1 integrin (VLA-4) affinity. J. Cell Sci. 104: 1049-1059 [Abstract]
Lasky, L. (1992). Selectins: interpreters of cell-specific carbohydrate information during inflammation. Science 258: 964-969 [Abstract]
Hu, M.C.-T., Siegelman, M.H., Holzmann, B., Crowe, D.T., Weissman, I.L. (1992). Lymphocyte Homing Receptors. Cold Spring Harb Symp Quant Biol 57: 291-308 [Abstract]
Freedman, A., Munro, J., Rice, G., Bevilacqua, M., Morimoto, C, McIntyre, B., Rhynhart, K, Pober, J., Nadler, L. (1990). Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110. Science 249: 1030-1033 [Abstract]
Siegelman, M., van de Rijn, M, Weissman, I. (1989). Mouse lymph node homing receptor cDNA clone encodes a glycoprotein revealing tandem interaction domains. Science 243: 1165-1172 [Abstract]
Heimfeld, S., Guidos, C.J., Holzmann, B., Siegelman, M.H., Weissman, I.L. (1989). Developmental Analysis of the Mouse Hematolymphoid System. Cold Spring Harb Symp Quant Biol 54: 75-85 [Abstract]
Jalkanen, S, Steere, A., Fox, R., Butcher, E. (1986). A distinct endothelial cell recognition system that controls lymphocyte traffic into inflamed synovium. Science 233: 556-558 [Abstract]
Siegelman, M, Bond, M., Gallatin, W., St John, T, Smith, H., Fried, V., Weissman, I. (1986). Cell surface molecule associated with lymphocyte homing is a ubiquitinated branched-chain glycoprotein. Science 231: 823-829 [Abstract]
St John, T, Gallatin, W., Siegelman, M, Smith, H., Fried, V., Weissman, I. (1986). Expression cloning of a lymphocyte homing receptor cDNA: ubiquitin is the reactive species. Science 231: 845-850 [Abstract]
Bjerknes, M, Cheng, H, Ottaway, C. (1986). Dynamics of lymphocyte-endothelial interactions in vivo. Science 231: 402-405 [Abstract]
Rosen, S., Singer, M., Yednock, T., Stoolman, L. (1985). Involvement of sialic acid on endothelial cells in organ-specific lymphocyte recirculation. Science 228: 1005-1007 [Abstract]
Netland, P., Zetter, B. (1984). Organ-specific adhesion of metastatic tumor cells in vitro. Science 224: 1113-1115 [Abstract]