Journal of Experimental Medicine, Vol 144, 685-698, Copyright © 1976 by Rockefeller University Press

ARTICLES

Selective expression of H-2 (i-region) loci controlling determinants on helper and suppressor T lymphocytes

K Okumura, LA Herzenberg, DB Murphy, HO McDevitt and LA Herzenberg

Data presented here show that locidentify in the I-region of the H-2 gene complex are selectively expressed in different functional T-cell subpopulations. These loci are closely linked (or possibly identical) to loci that control immune responses. They control surface determinants which identify helper and suppressor T lymphocytes. Determinants described here on allotype suppressor T cells (Ts) are found on normal (nonsuppressed) lymphoid cells, but are not found on helper T cells (Th). These determinants are controlled by a locus mapping in the I region of the H-2 complex. In an accompanying publication we show that this locus (Ia-4) marks a new I subregion (I- J) and is expressed only on T cells. Thus Ia-4 determinants idenfity a T-cell subpopulation which includes Ts but not Th. Th also carry identifying surface determinants controlled by loci that map to the H-2 complex, probably within the I region. These determinants are not found on Ts. Data presented also establish that loci in the I region control determinants on Th, but do not conclusively demonstrate that these are the determinants that distinguish Th from Ts. The selective expression of H-2-controlled determinants on Ts and Th suggests that these determinants are directly involved in immunoregulation.
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This article has been cited by other articles:

• Ishiguro, N., Brown, G. D., Ishizu, A., Meruelo, D. (1998). The Regulation of Murine H-2Dd Expression by Activation Transcription Factor 1 and cAMP Response Element Binding Protein. J. Immunol. 160: 5907-5914 [Abstract] [Full Text]  
• Herzenberg, L. A., Herzenberg, L. A., Black, S. J., Loken, M. R., Okumura, K., van der Loo, W., Osborne, B. A., Hewgill, D., Goding, J. W., Gutman, G., Warner, N. L. (1977). Surface Markers and Functional Relationships of Cells Involved in Murine B-lymphocyte Differentiation. Cold Spring Harb Symp Quant Biol 41: 33-45 [Abstract]  
• Murphy, D. B., Okumura, K., Herzenberg, L. A., Herzenberg, L. A., McDevitt, H. O. (1977). Selective Expression of Separate I-region Loci in Functionally Different Lymphocyte Subpopulations. Cold Spring Harb Symp Quant Biol 41: 497-504 [Abstract]  

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