Journal of Experimental Medicine, Vol 144, 654-661, Copyright © 1976 by Rockefeller University Press
Genetic regulation of the antibody response to H-2Db alloantigens in mice. III. Inhibition of the IgG Response to noncongenic cells by preimmunization with congenic cells
D Wernet, H Shafran and F Lilly
When B10.A (5R) mice (H-12i5) are immunized with spleen cells from congenic
B10 mice (H-12b), they respond to alloantigens of the H-2Db region by
producing antibodies of only IgM type. In contrast, they produce both IgM
and IgG antibodies when immunized with A.BY cells (H- 2b) that carry other
foreign cell surface antigens (non-H-2) in addition to H-2Db.
Preimmunization of 5R mice with two injections of congenic cells leads to
an H-2Db specific inhibition of the IgG response to a subsequent
immunization with A.BY cells. It is concluded that congenic B10 cells fail
to activate helper T cells which are necessary to induce the switch from
IgM to IgG production. Instead T- or B-cell tolerance may be induced with
prohibits the subsequent IgG response to A.BY cells, possibly by way of
suppressor T cells which may act either on B cells directly or via helper T
cells.
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