The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 144, 288-292, Copyright © 1976 by Rockefeller University Press

ARTICLES

Suppression of reaginic antibody (IgE) formation in mice by treatment with anti-mu antiserum

DD Manning, JK Manning and ND Reed

Neonatally initiated injection of anti-mu antiserum in mice has been shown to suppress the formation of reaginic antibodies in response to infection with the intestinal nematode, Nippostrongylus brasiliensis. This observation supports the hypothesis that IgE-producing cells arise from IgM-bearing precursors.
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