Journal of Experimental Medicine, Vol 144, 123-144, Copyright © 1976 by Rockefeller University Press

ARTICLES

Antibody response of C3H in equilibrium (CKB X CWB)F1 tetraparental mice to poly-L(Tyr,Glu)-poly-D,L-Ala-poly-L-Lys immunization

KB Bechtol and HO McDevitt

To test whether the antigen-specific stimulation of low responder- genotype B cells in tetraparental mice is due to a histoincompatibility reaction (allogeneic effect) against these B cells, tetraparental mice were constructed (a) between an Ir-1A low responder to the antigen poly- L(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys. [(T,G)-A--L] and an Ir-1A F1 high responder and (b) between two histoincompatible Ir-lA low responders. In the first case the F1 high responder embryo shares the whole of the H-2 complex, including Ir, with the low responder embryo.
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This article has been cited by other articles:

• McDevitt, H. O., Delovitch, T. L., Press, J. L. (1977). Functional and Genetic Analysis of Ia Antigens. Cold Spring Harb Symp Quant Biol 41: 489-496 [Abstract]  
• Boehmer, H. v., Sprent, J., Haas, W. (1977). The Influence of H-2 Gene Products on Cell-mediated and Humoral Immune Responses. Cold Spring Harb Symp Quant Biol 41: 539-545 [Abstract]  

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