The Journal of Experimental Medicine
VeriKine-HS Human IFN-Beta
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Journal of Experimental Medicine, Vol 144, 10-19, Copyright © 1976 by Rockefeller University Press

ARTICLES

Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression

MA Vadas, JF Miller, IF McKenzie, SE Chism, FW Shen, EA Boyse, JR Gamble and AM Whitelaw

The Ly and Ia phenotypes of T lymphocytes involved in different functions were characterized by the use of specific antisera. T cells responsible for delayed-type hypersensitivity (DTH) and for helper functions were found to be Ly-1+,2- in contrast to cytotoxic T cells and T cells responsible for suppression of antibody responses which were Ly-1-,2+. Unlike some primed helper cells, T cells involved in DTH were Ia-. Suppressor cells in the system were Ia+.
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