Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay

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Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay

MJ Bevan

Cytotoxic effector T cells of F1 (BALB/c X BALB.B) (H-2d/b) mice immunized against the minor histocompatibility differences of C57BL/10 (H-2b) can lyse targets from C57BL/10, but cannot lyse B10.D2 (H-2d) targets. Despite this lack of cross-reaction in the cytotoxic assay, C57BL/10 cells do prime F1 (BALB/c X BALB.B) mice for a secondary cytotoxic response to B10.D2. C57BL/10-primed, B10.D2-boosted cytotoxic cells lyse B10.D2 targets but not C57BL/10 targets. DBA/2 (H-2d) spleen cells or thymocytes prime F1 mice for a secondary response to DBA/2, B10.D2, and C57BL/10 cells, but DBA/2 mastocytes, P815, do not prime for a response to C57BL/10. Whether H-2 congenic lymphoid cells express minor histocompatibility determinants which cross-react at the cytotoxic T-cell level or the helper T-cell level is discussed.
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Hernandez, J., Aung, S., Marquardt, K., Sherman, L. A. (2002). Uncoupling of Proliferative Potential and Gain of Effector Function by CD8+ T Cells Responding to Self-Antigens. JEM 196: 323-333 [Abstract] [Full Text]
Legge, K. L., Gregg, R. K., Maldonado-Lopez, R., Li, L., Caprio, J. C., Moser, M., Zaghouani, H. (2002). On the Role of Dendritic Cells in Peripheral T Cell Tolerance and Modulation of Autoimmunity. JEM 196: 217-227 [Abstract] [Full Text]
Marsac, D., Loirat, D., Petit, C., Schwartz, O., Michel, M.-L. (2002). Enhanced Presentation of Major Histocompatibility Complex Class I-Restricted Human Immunodeficiency Virus Type 1 (HIV-1) Gag-Specific Epitopes after DNA Immunization with Vectors Coding for Vesicular Stomatitis Virus Glycoprotein- Pseudotyped HIV-1 Gag Particles. J. Virol. 76: 7544-7553 [Abstract] [Full Text]
Kalergis, A. M., Ravetch, J. V. (2002). Inducing Tumor Immunity through the Selective Engagement of Activating Fc{gamma} Receptors on Dendritic Cells. JEM 195: 1653-1659 [Abstract] [Full Text]
Schulz, O., Pennington, D. J., Hodivala-Dilke, K., Febbraio, M., Reis e Sousa, C. (2002). CD36 or {alpha}v{beta}3 and {alpha}v{beta}5 Integrins Are Not Essential for MHC Class I Cross-Presentation of Cell-Associated Antigen by CD8{alpha}+ Murine Dendritic Cells. J. Immunol. 168: 6057-6065 [Abstract] [Full Text]
Belz, G. T., Vremec, D., Febbraio, M., Corcoran, L., Shortman, K., Carbone, F. R., Heath, W. R. (2002). CD36 Is Differentially Expressed by CD8+ Splenic Dendritic Cells But Is Not Required for Cross-Presentation In Vivo. J. Immunol. 168: 6066-6070 [Abstract] [Full Text]
Parmiani, G., Castelli, C., Dalerba, P., Mortarini, R., Rivoltini, L., Marincola, F. M., Anichini, A. (2002). Cancer Immunotherapy With Peptide-Based Vaccines: What Have We Achieved? Where Are We Going?. JNCI J Natl Cancer Inst 94: 805-818 [Abstract] [Full Text]
Moron, G., Rueda, P., Casal, I., Leclerc, C. (2002). CD8{alpha}2 CD11b+ Dendritic Cells Present Exogenous Virus-like Particles to CD8+ T Cells and Subsequently Express CD8{alpha} and CD205 Molecules. JEM 195: 1233-1245 [Abstract] [Full Text]
Wen, Y.-J., Min, R., Tricot, G., Barlogie, B., Yi, Q. (2002). Tumor lysate-specific cytotoxic T lymphocytes in multiple myeloma: promising effector cells for immunotherapy. Blood 99: 3280-3285 [Abstract] [Full Text]