The Journal of Experimental Medicine
Avanti Polar Lipids, Inc.
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Journal of Experimental Medicine, Vol 143, 1277-1282, Copyright © 1976 by Rockefeller University Press

ARTICLES

The HLA system in the families of patients with juvenile diabetes mellitus

P Rubinstein, N Suciu-Foca, JF Nicholson, M Fotino, A Molinaro, L Harisiadis, MA Hardy, K Reemtsma and FH Allen Jr

The HLA and Bf genotypes were determined in 10 families with one or more children with JDM. A statistically significant association was found between HLA-D-identity and the chance to present JDM within a sibship. No such association was detectable with the SD antigens. A highly significant increase in the frequency of intra-HLA recombination was also found in these families.
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