Journal of Experimental Medicine, Vol 143, 372-381, Copyright © 1976 by Rockefeller University Press

ARTICLES

Effects of anti-Ia sera on mitogenic responses. II. Differential expression of the Ia marker on phytohemagglutinin and concanavalin A- reactive T cells

JE Niederhuber, JA Frelinger, MS Dine, P Shoffner, E Dugan and DC Shreffler

Genes mapping in the I region of the H-2 complex control a system of lymphocyte alloantigens (Ia) which are expressed on a subpopulation of T cells and on most B cells. Specific anti-Ia serum in the presence of rabbit complement removed the splenic T-cell subpopulation responsive to Con-A, but did not affect the response to phytohemagglutinin (PHA) or Leucoagglutinin. Antibodies specific for Ia, H-2K, or H-2D membrane antigens were used without complement to pretreat spleen cells. These antibody pretreated cells responded normally to Con-A and PHA.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• Shreffler, D. C., David, C. S., Cullen, S. E., Frelinger, J. A., Niederhuber, J. E. (1977). Serological and Functional Evidence for Further Subdivision of the I Regions of the H-2 Gene Complex. Cold Spring Harb Symp Quant Biol 41: 477-487 [Abstract]  
• Murphy, D. B., Okumura, K., Herzenberg, L. A., Herzenberg, L. A., McDevitt, H. O. (1977). Selective Expression of Separate I-region Loci in Functionally Different Lymphocyte Subpopulations. Cold Spring Harb Symp Quant Biol 41: 497-504 [Abstract]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS