The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 143, 206-210, Copyright © 1976 by Rockefeller University Press

ARTICLES

Genetic control of cutaneous basophil hypersensitivity

M Stadecker and S Leskowitz

CBH to DNP-GL could be elicited only in responder guinea pigs which possess the genetic ability to develop classic delayed type hypersensitivity to DNP-PLL, the response to which is governed by the same gene. Since the defect in nonresponder animals seems to reside at the level of their T cells and not B cells, these results lend support to the contention that CBH, as well as DH, is dependent on and probably mediated by T cells.
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