The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 142, 1600-1605, Copyright © 1975 by Rockefeller University Press

ARTICLES

Activated macrophages release a factor which lyses malignant cells but not normal cells

GA Currie and C Basham

When rat macrophages are activated by exposure to bacterial endotoxin they acquire the capacity to lyse sarcoma cells in tissue culture. Although showing no immunological specificity this lytic effect was only detectable on malignant cells; normal cells were unaffected. This tumor-selective lytic effect is mediated by a labile supernatant product.
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