The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 142, 1301-1305, Copyright © 1975 by Rockefeller University Press

ARTICLES

Cell-mediated immunity: differential maturation of mixed leukocyte reaction and cell-mediated lympholysis

S Wu, FH Bach and R Auerbach

While spleen cells from neonatal B10 (H-2b) are reactive (proliferate) in one-way mixed leukocyte culture, cell-mediated lympholysis reactivity does not arise until 7 days of age. When B10 cells are sensitized to B10.D2 (H-2d), cross-killing of third-party B10.BR (H-2k) target is always lower than the specific killing of B10.D2 targets and is not demonstrable until 27 days after birth.
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