Measles infection of human mononuclear cells. I. Acute infection of peripheral blood lymphocytes and monocytes

doi:10.1084/jem.142.3.773

This Article

	Full Text (PDF, 799K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Sullivan, J. L.
	Articles by Albrecht, P.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Sullivan, J. L.
	Articles by Albrecht, P.


Social Bookmarking

	What's this?

ARTICLES

Measles infection of human mononuclear cells. I. Acute infection of peripheral blood lymphocytes and monocytes

JL Sullivan, DW Barry, SJ Lucas and P Albrecht

A study of the susceptibility of human peripheral blood mononuclear cells to measles virus infection and replication is reported. Resting lymphocytes obtained from adults showed very low levels of infection and virus replication while lymphocytes activated by plant mitogens or allogenic lymphocytes supported mononuclear cells obtained from the umbilical cord of healthy neonates were more susceptible to measles virus infection than those of adults; however, activated cord lymphocytes supported viral replication in the range observed with adult activated lymphocytes. Monocytes obtained from adults were relatively resistant to measles virus infection and replication while neonatal cord blood monocytes supported viral replication to the degree observed with activated lymphocytes. It is hypothesized that infection of acitivated lymphocytes may explain the depression of cell-mediated immunity seen during acute measles virus infection. The significance of the finding that neonatal monocytes are more susceptible to viral infection and replication than adult monocytes is discussed.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Permar, S. R., Griffin, D. E., Letvin, N. L. (2006). Immune Containment and Consequences of Measles Virus Infection in Healthy and Immunocompromised Individuals. CVI 13: 437-443 [Full Text]
Hahm, B., Arbour, N., Naniche, D., Homann, D., Manchester, M., Oldstone, M. B. A. (2003). Measles Virus Infects and Suppresses Proliferation of T Lymphocytes from Transgenic Mice Bearing Human Signaling Lymphocytic Activation Molecule. J. Virol. 77: 3505-3515 [Abstract] [Full Text]
Grimley, P. M., Fang, H., Rui, H., Petricoin III, E. F., Ray, S., Dong, F., Fields, K. H., Hu, R., Zoon, K. C., Audet, S., Beeler, J. (1998). Prolonged STAT1 Activation Related to the Growth Arrest of Malignant Lymphoma Cells by Interferon-alpha. Blood 91: 3017-3027 [Abstract] [Full Text]
Grosjean, I., Caux, C., Bella, C., Berger, I., Wild, F., Banchereau, J., Kaiserlian, D. (1997). Measles Virus Infects Human Dendritic Cells and Blocks Their Allostimulatory Properties for CD4+ T Cells. JEM 186: 801-812 [Abstract] [Full Text]
Oldstone, M.�B.�A. (1996). Virus-lymphoid cell�interactions. Proc. Natl. Acad. Sci. USA 93: 12756-12758 [Full Text]
Schlender, J., Schnorr, J.-J., Spielhofer, P., Cathomen, T., Cattaneo, R., Billeter, M.�A., ter�Meulen, V., Schneider-Schaulies, S. (1996). Interaction of measles virus glycoproteins with the surface of uninfected peripheral blood lymphocytes induces immunosuppression in�vitro. Proc. Natl. Acad. Sci. USA 93: 13194-13199 [Abstract] [Full Text]