Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate across allogeneic barriers

doi:10.1084/jem.142.3.694

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Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate across allogeneic barriers

MJ Taussig, AJ Munro, R Campbell, CS David and NA Staines

Further mapping of the mouse T-cell factor specific for poly(Try,Glu)- polyD-LAla--polyLys is reported. It is shown to be a product of the I-A subregion of the H-2 complex by the use of antisera either raised specifically against or made specific, by absorption, for different regions of the H-2 complex. The factor cooperates across allogeneic barriers, e.g., when factor produced by one strian is combined with bone marrow cells of other H-2 incompatible strains.
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Tada, T., Taniguchi, M., David, C. S. (1977). Suppressive and Enhancing T-cell Factors as I-region Gene Products: Properties and the Subregion Assignment. Cold Spring Harb Symp Quant Biol 41: 119-127 [Abstract]
McDevitt, H. O., Delovitch, T. L., Press, J. L. (1977). Functional and Genetic Analysis of Ia Antigens. Cold Spring Harb Symp Quant Biol 41: 489-496 [Abstract]
Swain, S. L., Trefts, P. E., Tse, H. Y.-S., Dutton, R. W. (1977). The Significance of T-B Collaboration across Haplotype Barriers. Cold Spring Harb Symp Quant Biol 41: 597-609 [Abstract]