Journal of Experimental Medicine, Vol 142, 84-89, Copyright © 1975 by Rockefeller University Press

ARTICLES

Detection of antigens specific for B-lymphoid cultured cell lines with human alloantisera

DL Mann, L Abelson, S Harris and DB Amos

Human sera were tested for cytotoxicity to pairs of long-term tissue- cultured cell lines. Each pair had been derived from the same individual and one of the pairs possessed the characteristics of either "T" or "B" cells. The alloantisera used were HL-A-typing reagents or sera obtained from Amish multiparas. Selected cytotoxicity was found against the B-cell lines by direct testing. Cytotoxicity was abolished by absorption with B-cell line but not by absorption with the T-cell lines. The results suggest that a group of allotypic antigens may be expressed exculsively on human B cells.
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This article has been cited by other articles:

• Moutsopoulos, H., Chused, T., Johnson, A., Khudsen, B, Mann, D. (1978). B lymphocyte antigens in sicca syndrome. Science 199: 1441-1442 [Abstract]  
• Springer, T. A., Kaufman, J. F., Siddoway, L. A., Giphart, M., Mann, D. L., Terhorst, C., Strominger, J. L. (1977). Chemical and Immunological Characterization of HL-A-linked B-lymphocyte Alloantigens. Cold Spring Harb Symp Quant Biol 41: 387-396 [Abstract]  
• Ferrone, S, Pellegrino, M., Cooper, N. (1976). Expression of C4 on human lymphoid cells and possible involvement in immune recognition phenomena. Science 193: 53-55 [Abstract]  
• McFarlin, D. E., McFarland, H. F. (1976). Histocompatibility Studies and Multiple Sclerosis. Arch Neurol 33: 395-398 [Abstract]  

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