Journal of Experimental Medicine, Vol 142, 253-258, Copyright © 1975 by Rockefeller University Press

ARTICLES

Genetical control of B-cell responses. IV. Inheritance of the unresponsiveness to lipopolysaccharides

A Coutinho, G Moller and E Gronowicz

The inheritance of B-cell responsiveness to lipopolysaccharide (LPS) was studied in 55 crosses between mice of the low-responder strain C3H/HeJ and the high-responder strains B10.5M and C3H/Tif. F1 hybrid mice between the low-and the high-responder strains, showed in every case responses which were intermediate between the responses obtained with each parent. The responsiveness among F2 hybrid and backcross mice to either high- or low-responder parents, segregated into intermediate, high, or low categories, respectively. The present results are compatible with the hypothesis that responsiveness to LPS is determined by one single, codominantly expressed, autosomal gene. The capacity to develop a specific thymus-independent response to a hapten-LPS conjugate, also under genetical control, was found to segregate together with the capacity to develop polyclonal responses to LPS.
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This article has been cited by other articles:

• Rodo, J., Goncalves, L. A., Demengeot, J., Coutinho, A., Penha-Goncalves, C. (2006). MHC Class II Molecules Control Murine B Cell Responsiveness to Lipopolysaccharide Stimulation. J. Immunol. 177: 4620-4626 [Abstract] [Full Text]  
• Vogel, S. N., Johnson, D., Perera, P.-Y., Medvedev, A., Lariviere, L., Qureshi, S. T., Malo, D. (1999). Cutting Edge: Functional Characterization of the Effect of the C3H/HeJ Defect in Mice that Lack an Lpsn Gene: In Vivo Evidence for a Dominant Negative Mutation. J. Immunol. 162: 5666-5670 [Abstract] [Full Text]  

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