Journal of Experimental Medicine, Vol 142, 120-138, Copyright © 1975 by Rockefeller University Press
Histocompatibility studies in a closely bred colony of dogs. V. Mechanisms of cellular adaptation in long-term DL-A identical radiation chimeras
FT Rapaport, HS Lawrence, R Bachvaroff, FD Cannon, D Blumenstock, N Mollen, JH Ayvazian and JW Ferrebee
20 Cooperstown beagles of known DL-A genotypes (B" dogs) were exposed to
supralethal total body irradiation and received a bone marrow allograft
from a DL-A identical donor (A" dog); the resulting chimeras have survived
uneventfully for 882, 1466 days, with no evidence of secondary disease, and
have been tolerant to kidney and skin allografts obtained from the donor of
marrow. Treatment of "A" dogs with serum obtained from their long-term "B"
chimeras had no significant effect upon the ability of the recipients to
reject "B" skin allografts...
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