Journal of Experimental Medicine, Vol 141, 1216-1220, Copyright © 1975 by Rockefeller University Press
Evidence for the involvement of the Ss protein of the mouse in the hemolytic complement system
TH Hansen, HS Shin and DC Shreffler
A significant within-strain correlation has been demonstrated between the
levels of Ss and hemolytic complement (C) activity in two Ss-high strains.
Mouse serum specifically depleted of Ss by absorption with F(ab')2
fragments of anti-Ss had negligible C activity. In control experiments,
Ss-specific antigen-antibody complexes formed with F(ab')2 fragments did
not fix rabbit C, and bovine serum albumin-specific antigen-antibody
complexes formed with F(ab')2 fragments did not fix mouse C. Therefore the
removal of C activity by anti-Ss [F(ab')2] was apparently not due to C
fixation. These results suggest that the Ss protein is a necessary
component of the C system.
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