Journal of Experimental Medicine, Vol 141, 1047-1056, Copyright © 1975 by Rockefeller University Press

ARTICLES

Induction of resistance to antibody-mediated cytotoxicity. H-2, Ia, and Ig antigens are independent entities in the membrane of mouse lymphocytes

V Hauptfeld, M Hauptfeld and J Klein

Mouse spleen or thymus lymphocytes incubated with monospecific H-2 or Ia alloantisera and then coated with a xenogeneic antimouse Ig serum become specifically resistant to the alloantiserum (and complement) they have been incubated with. This so called "lysostrip method" was used to investigate the molecular interrelationships of antigens in the mouse lymphocyte membrane. The results of this investigation confirm that H-2K and H-2D antigens are carried by two distinct populations of molecules. They provide evidence that the Ia antigens move in the membrane independently of both H2-K and H-2D antigens; and finally they demonstrate absence of any physical linkage between Ig receptors in B cells, on the one hand, and Ia, H-2K, and H-2D molecules on the other hand.
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This article has been cited by other articles:

• Cunningham, B. A., Henning, R., Milner, R. J., Reske, K., Ziffer, J. A., Edelman, G. M. (1977). Structure of Murine Histocompatibility Antigens. Cold Spring Harb Symp Quant Biol 41: 351-362 [Abstract]  
• Schrader, J. W., Henning, R., Milner, R. J., Edelman, G. M. (1977). The Recognition of H-2 and Viral Antigens by Cytotoxic T Cells. Cold Spring Harb Symp Quant Biol 41: 547-557 [Abstract]  

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