Correlation of early murine leukemia virus titer and H-2 type with spontaneous leukemia in mice of the BALB/c times AKR cross: a genetic analysis

This Article

	Full Text (PDF, 483K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Lilly, F
	Articles by Rowe, W.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Lilly, F
	Articles by Rowe, W.


Social Bookmarking

	What's this?

ARTICLES

Correlation of early murine leukemia virus titer and H-2 type with spontaneous leukemia in mice of the BALB/c times AKR cross: a genetic analysis

F Lilly, ML Duran-Reynals and WP Rowe

Tissue extracts from 6-wk old mice of the AKR strain (H-K) show high levels of infectious murine leukemia virus, and these mice show a near 100% incidence of spontaneous leukemia. In F1 mice of the cross, BALB/c times AKR (H-2K/H-2K), both the occurrence of virus and the incidence of spontaneous leukemia are suppressed to very low values, due largely to the presence of the FV-1b allele inherited from the BALB/c parent. Mice of the (BALB/c times AKR) F-1 times AKR backcross generation were observed for possible correlations between virus expressions at 6 wk of age, H-2 type and leukemia incidence. H-2 type showed at most a weak influence on the occurrence of infectious virus, but there was a very strong correlation between the level of virus expression and the occurrence of leukemia and a strong correlation between H-2 type and leukemia. In addition, there was a highly significant nonrandom distribution of virus-negative mice among the backcross litters, suggesting a maternal effect on virus expression.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Kamath, A. B., Alt, J., Debbabi, H., Taylor, C., Behar, S. M. (2004). The Major Histocompatibility Complex Haplotype Affects T-Cell Recognition of Mycobacterial Antigens but Not Resistance to Mycobacterium tuberculosis in C3H Mice. Infect. Immun. 72: 6790-6798 [Abstract] [Full Text]
Ristevski, S., Purcell, D. F.�J., Marshall, J., Campagna, D., Nouri, S., Fenton, S. P., McPhee, D. A., Kannourakis, G. (1999). Novel Endogenous Type D Retroviral Particles Expressed at High Levels in a SCID Mouse Thymic Lymphoma. J. Virol. 73: 4662-4669 [Abstract] [Full Text]
Leonard, J., Abramczuk, J., Pezen, D., Rutledge, R, Belcher, J., Hakim, F, Shearer, G, Lamperth, L, Travis, W, Fredrickson, T, et, al. (1988). Development of disease and virus recovery in transgenic mice containing HIV proviral DNA. Science 242: 1665-1670 [Abstract]
Lowy, D. R., Rands, E., Chattopadhyay, S. K., Hager, G. L. (1980). Structure and Infectivity of Integrated Murine Leukemia Virus DNA. Cold Spring Harb Symp Quant Biol 44: 1143-1151 [Abstract]
Lung, M. L., Hering, C., Hartley, J. W., Rowe, W. P., Hopkins, N. (1980). Analysis of the Genomes of Mink Cell Focus-inducing Murine Type-C Viruses: A Progress Report. Cold Spring Harb Symp Quant Biol 44: 1269-1274 [Abstract]
Famulari, N. G., Tung, J.-S., O'Donnell, P. V., Fleissner, E. (1980). Murine Leukemia Virus env-gene Expression in Preleukemic Thymocytes and Leukemia Cells of AKR Strain Mice. Cold Spring Harb Symp Quant Biol 44: 1281-1287 [Abstract]
Ihle, J., Joseph, D., Domotor, J. Jr (1979). Genetic linkage of C3H/HeJ and BALB/c endogenous ecotropic C-type viruses to phosphoglucomutase-1 on chromosome 5. Science 204: 71-73 [Abstract]
Peebles, P., Scolnick, E., Howk, R. (1976). Increased sarcoma virus RNA in cells transformed by leukemia viruses: model for leukemogenesis. Science 192: 1143-1145 [Abstract]