The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 140, 1579-1587, Copyright © 1974 by The Rockefeller University Press

ARTICLE

ANTIGEN-SPECIFIC T-CELL FACTOR IN CELL COOPERATION: PHYSICAL PROPERTIES AND MAPPING IN THE LEFT-HAND (K) HALF OF H-2

A. J. Munro 1, M. J. Taussig 1, Rosalie Campbell 1, Heather Williams 1, and Yvonne Lawson 1

1 From The Immunology Division, Department of Pathology, University of Cambridge, Cambridge, England

Mouse thymus cells, educated to poly(tyrosyl,glutamyl)-polyDLalanyl--polylysyl [(T,G)-A--L], release an antigen-specific factor on brief culture in vitro. The factor cooperates with bone marrow cells in the antibody response to (T,G)-A--L in irradiated recipients. Its mol wt determined from Sephadex G100 chromatography is in the region of 50,000. The factor is removed by specific antigen-coated columns, but not by anti-immunoglobulin (anti-Fab, anti-µ, anti-Fv) adsorbents. The factor is removed by alloantisera directed against the H-2 haplotype of the strain in which it is produced. Moreover, only antisera with specificity for the K side of H-2 were successful in removing the factor activity.

Submitted on July 23, 1974


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