The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 140, 1457-1467, Copyright © 1974 by The Rockefeller University Press

ARTICLE

HOST GENETIC CONTROL OF RECOVERY FROM FRIEND LEUKEMIA VIRUS-INDUCED SPLENOMEGALY : Mapping of a Gene Within the Major Histocompatability Complex



Bruce Chesebro 1, Kathy Wehrly 1, and Jack Stimpfling 1

1 From the U. S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, and the McLaughlin Research Institute, Great Falls, Montana 59401

The influence of the major mouse histocompatibility gene complex (H-2) on the response of mice to Friend leukemia virus was studied in F1 congenic mice differing only at genes within the H-2 complex. F1 mice which were H-2b/b had a high incidence of recovery from splenomegaly compared to H-2b/d or H-2b/a mice. In mice with recombinations within the H-2 complex a gene (designated RFV-1), responsible for the Friend virus recovery effect, was found to map near or within the D region of serologically detectable transplantation antigens. Because the incidence of recovery was much higher in F1 H-2b/b mice than in parental H-2b/b mice, other non-H-2 host genetic factors also appear to be important to expression of recovery in H-2b/b F1 mice. The mechanisms of action of these genes remain unknown.


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