The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 140, 1432-1437, Copyright © 1974 by The Rockefeller University Press


BRIEF DEFINITIVE REPORTS

GENETIC CORRELATION OF A MOUSE LIGHT CHAIN VARIABLE REGION MARKER WITH A THYMOCYTE SURFACE ANTIGEN

Paul D. Gottlieb 1

1 From the Center for Cancer Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

The inbred and congenic strain distribution of the IH-peptide marker in the variable region of mouse immunoglobulin light chains has been compared with other known genetic markers. A positive correlation was noted between the IH-peptide marker and expression of the Ly-3.1 thymocyte cell surface antigen. This suggests that the locus responsible for IH-peptide expression is genetically linked to the Ly-2 and Ly-3 loci in linkage group XI on chromsome 6 of the mouse.

Submitted on August 13, 1974


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