The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 140, 859-864, Copyright © 1974 by The Rockefeller University Press

BRIEF DEFINITIVE REPORTS

CHARACTERIZATION OF A NEW INTRA-H-2 RECOMBINANT : SEPARATION OF THE Ir-RE AND Ir-GLT GENES



Martin E. Dorf 1, Frank Lilly 1, and Baruj Benacerraf 1

1 From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, and the Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461

This report characterizes the intra-H-2 crossover in the D2.GD mouse strain. Recombination occurred within the I region between the immune response (Ir) gene controlling immune responsiveness to ragweed extract (RE). Ir-RE, and the Ir gene governing responsiveness to the random linear terpolymers of glutamic acid and lysine with either tyrosine or pheylalanine (Ir-GLT and Ir-GLphi). The Ir-RE gene was tentatively located in the Ir-1A subregion and the Ir-GLT and Ir-GLphi gene(s) tentatively placed in the Ir-1B subregion. The importance of this recombinant strain to further studies on the fine structure of the I region is discussed.

Submitted on June 17, 1974


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