The Journal of Experimental Medicine
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An erratum to this article has been published: Andersson et al., J. Exp. Med. 140 (6) 1437
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The Journal of Experimental Medicine, Vol 140, 742-763, Copyright © 1974 by The Rockefeller University Press

ARTICLE

IgM-PRODUCING TUMORS IN THE BALB/c MOUSE : A MODEL FOR B-CELL MATURATION



Jan Andersson 1, Joel Buxbaum 1, Ronald Citronbaum 1, Steven Douglas 1, Luciana Forni 1, Fritz Melchers 1, Benvenuto Pernis 1, and David Stott 1

1 From the Basel Institute for Immunology, CH- 4058 Basel, Switzerland, the Manhattan Veterans Administration Hospital, New York, 10010, and the Mt. Sinai School of Medicine, New York, 10029

Five adjuvant induced BALB/c tumors producing IgM—McPc 1748, W 3469, TEPC 183, McPc 774, and Y 5781—were characterized morphologically by electron microscopy, analysis of the distribution of surface-bound and intracytoplasmic IgM using immunofluorescence, and by biochemical study of IgM synthesis, turnover, and secretion. The cells of different tumors appear to represent different stages in B-cell maturation when compared to normal, lipopolysaccharide-stimulated B cells. Thus, McPc 1748 tumor cells resemble 10–25-h stimulated normal B cells, 3469 cells resemble 20–35-h stimulated B cells, TEPC 183 cells resemble 45–65-h stimulated B cells, Y 5781 cells resemble 80–110-h stimulated B cells, and McPc 774 cells resemble 100–130-h stimulated B cells.

Submitted on May 30, 1974


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