The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 140, 538-548, Copyright © 1974 by The Rockefeller University Press

ARTICLE

IMMUNOLOGICAL FUNCTIONS OF HUMAN T-LYMPHOID CELL LINE (MOLT) : I. RELEASE OF IMMUNOSUPPRESSIVE FACTORS FROM THE MIXTURE OF MOLT-4 CELLS AND SHEEP RED BLOOD CELLS



Akikazu Takada 1, Yumiko Takada 1, and Jun Minowada 1

1 From the Springville Laboratories and the Department of Immunology and Immunochemistry, Roswell Park Memorial Institute, Springville, New York 14141

A short term incubation of the mixture of established human T-lymphoid cells (MOLT) and sheep red blood cells (SRBC) resulted in the release of factors which nonspecifically suppressed the response of mouse spleen cells against heterologous erythrocytes in vitro. Neither human B-cell line (RPMI 1788), nor the supernate of MOLT cell suspension in the absence of SRBC had such suppressive effects.

The supernate of the mixture of MOLT cells with chicken red blood cells (CRBC) did not suppress either anti-CRBC or anti-SRBC responses of mouse spleen cells. Since CRBC did not form rosettes with MOLT cells, it is suspected that the origin of the production of these factors might be MOLT cells forming SRBC rosettes. Some of these factors are dialysable.

 Submitted on March 9, 1974


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