The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 139, 1361-1367, Copyright © 1974 by The Rockefeller University Press

BRIEF DEFINITIVE REPORTS

CLONAL MEMORY : I. TIME-COURSE OF PROLIFERATION OF B-MEMORY CELLS



A. J. McMichael 1 and A. R. Williamson 1

1 From the National Institute for Medical Research, Mill Hill, London NW7 1AA England

A single clone of B cells producing anti-DNP antibody recognizable by the isoelectric-focusing spectrum has been used, in a double transfer system, to study clonal memory. Trasnsferable B memory develops between 4 and 7 days after the first transfer with antigen. B-memory cells thus proliferate before or concomitantly with antibody-forming cells.

Submitted on February 19, 1974


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