The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 139, 1354-1360, Copyright © 1974 by The Rockefeller University Press

BRIEF DEFINITIVE REPORTS

CELLULAR REQUIREMENTS FOR THE PRIMARY IN VITRO ANTIBODY RESPONSE TO DNP-FICOLL

D. E. Mosier 1, B. M. Johnson 1, W. E. Paul 1, and P. R. B. McMaster 1

1 From the Laboratory of Immunology and the Laboratory of Microbial Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

The cellular requirements for the primary in vitro IgM and IgG response to dinitrophenyl-substituted Ficoll were examined. Neither thymus-derived lymphocytes nor macrophage-rich splenic adherent cells were required for anti-DNP antibody synthesis. DNP-Ficoll is therefore tentatively classified as a "thymic-independent" antigen.

Submitted on February 26, 1974


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