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¹ From the Basel Institute for Immunology, CH4058 Basel, Switzerland

If nude mice are grafted with a neonatal thymus, host type precursor cells develop within the graft thymus and after about 6 wk the T-cell population of the thymus, spleen, and lymph nodes is of host type. However, immunological responsiveness produced in nude mice in this manner is incomplete: (a) the ability to react to T-cell mitogens in vitro is greater than in untreated nudes but lower than in normal mice; (b) the response to T-cell dependent antigens is less than normal; and (c) the rejection of skin grafts is slower than in normal animals. Whether host precursor cells which differentiate in an allogeneic thymus are able to reject skin grafts from thymus donor strain appears to depend on the strain combination used.

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This article has been cited by other articles:

• Salaun, J, Bandeira, A, Khazaal, I, Calman, F, Coltey, M, Coutinho, A, Le Douarin, N. (1990). Thymic epithelium tolerizes for histocompatibility antigens. Science 247: 1471-1474 [Abstract]  
• Schedi, M., Goldstein, G, Boyce, E. (1975). Differentiation of T cells in nude mice. Science 190: 1211-1213 [Abstract]  

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