The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 139, 1142-1153, Copyright © 1974 by The Rockefeller University Press

ARTICLE

ONTOGENY OF B LYMPHOCYTES : III. H-2 LINKAGE OF A GENE CONTROLLING THE RATE OF APPEARANCE OF COMPLEMENT RECEPTOR LYMPHOCYTES



Michael C. Gelfand 1, David H. Sachs 1, Rose Lieberman 1, and William E. Paul 1

1 From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, and the Immunology Branch of the National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

The frequency of lymphocytes bearing complement receptors in the spleens of 2-wk old mice appears to be controlled by two independent genes. The presence of a "high" allele at either locus leads to intermediate or high frequency of CRL at 2 wk of age. One of the genes controlling complement receptor lymphocyte (CRL) frequency (CRL-1) is linked to the H-2 complex. Thus, in progeny of (AKR x DBA/2)F1 x DBA/2, all mice with a low frequency of CRL at 2 wk of age are homozygous for the H-2 type of the low CRL parent (DBA/2). Furthermore, in the B10 series of congenic mice, CRL frequency at 2 wk of age is similar to the frequency in the donor of the H-2 region. Thus, C57BL/10, B10.BR, and B10-D2 mice are all of the low CRL type while B10.A mice are intermediate in CRL frequency at 2 wk. C57BR and DBA/2, the donors of the H-2 complex of the B10.BR and B10.D2, respectively, are of low CRL type while the A/WySn, the donor of the H-2 complex in the B10.A, is an intermediate CRL strain. Similarly in the A/WySn series of congenic mice, A.CA, A.SW, and A.BY are all low CRL strains while the A/WySn is intermediate.

Studies of CRL frequency in mice with recombinant H-2 chromosomes (B10.A(2R), (4R), and (5R); B6/TL+; and A/TL-) indicate that CRL-1 is to the right of the Ss-Slp genes and to the left of Tla.

 Submitted on January 21, 1974


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