The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 139, 1049-1060, Copyright © 1974 by The Rockefeller University Press

ARTICLE

CYTOTOXIC ACTIVITY OF MOUSE MACROPHAGES STUDIED BY VARIOUS INHIBITORS

Haakon Melsom 1

1 From Norsk Hydro's Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo 3, Norway

The influence of various inhibitors on the cytolytic potential of mouse macrophages against syngeneic erythrocytes has been investigated in vitro by isotope techniques. Intact macrophage membrane and cell metabolism was essential for full cytotoxic activity. The process was completely blocked by anaerobiosis and cold. ATP from both mitochondrial respiration and glycolysis seems to be the high energy intermediate which is utilized during the cytotoxic activity of macrophages leading to target cell lysis. The process did not depend on concomitant DNA transcription, translation, or protein synthesis.

Submitted on January 7, 1974


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