The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 139, 957-968, Copyright © 1974 by The Rockefeller University Press

ARTICLE

RELATIONSHIP BETWEEN HL-A ANTIGENS AND ß2-MICROGLOBULIN AS STUDIED BY IMMUNOFLUORESCENCE ON THE LYMPHOCYTE MEMBRANE

C. Neauport-Sautes 1, A. Bismuth 1, F. M. Kourilsky 1, and Y. Manuel 1

1 From the Laboratoire d'Immunologie des Tumeurs, Institut de Recherches sur les Maladies du Sang, Centre Hayem, Hôpital Saint Louis, 75010 Paris, France, and the Service d'Immuno-chimie, Institut Pasteur de Lyon, France.

The antibody-induced redistribution of ß2-microglobulin (ß2-µ) and HL-A antigens on the surface of living lymphocytes was studied by immunofluorescence. When all ß2-µ was redistributed on the lymphocyte membrane by specific rabbit antibodies and goat antirabbit Ig conjugates, the HL-A antigens were no more detectable with anti-HL-A conjugates outside the ß2-µ caps already formed. However, the redistribution of HL-A antigens fails to provoke the redistribution of all detectable ß2-µ molecules. These results suggest that HL-A antigens may be associated with ß2-µ at the cell surface, but that all ß2-µ molecules are not bound to HL-A antigens.

Submitted on December 26, 1973


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