The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 139, 1019-1024, Copyright © 1974 by The Rockefeller University Press

BRIEF DEFINITIVE REPORTS

A DEPRESSION OF CELL-MEDIATED IMMUNITY TO MEASLES ANTIGEN IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Virginia Utermohlen 1, John B. Winfield 1, John B. Zabriskie 1, and Henry G. Kunkel 1

1 From The Rockefeller University, New York 10021

Using the direct migration inhibition test, response to measles antigen in patients with systemic lupus erythematosus (SLE) was found to be decreased when compared with that of normal subjects. No alteration was observed in similar experiments using parainfluenza type 1 and rubella antigens. The specific decrease in measles antigen effect showed no obvious correlation with activity of SLE or with the presence of lymphocytotoxic antibodies. Whether the specificity of the decrease in reactivity is due to some particular relationship between the measles virus or antigen and SLE, or to the possibility that measles reactivity is a more sensitive indicator of a generalized defect of cell-mediated immunity, remains unclear.


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