The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 139, 512-527, Copyright © 1974 by The Rockefeller University Press

ARTICLE

CONGENIC MOUSE STRAINS: THE EXPRESSION OF A HIDDEN IMMUNOGLOBULIN ALLOTYPE IN A CONGENIC PARTNER STRAIN OF BALB/c MICE

Melvin J. Bosma 1 and Gayle C. Bosma 1

1 From The Institute for Cancer Research, Fox Chase Center for Cancer and Medical Sciences, Philadelphia, Pennsylvania 19111

This paper derives from the unexpected observations of the "wrong immunoglobulin allotype" in a congenic partner strain of BALB/c mice from the Institute of Cancer Research (ICR CB-17). These mice were specially bred so as not to differ from BALB/c mice in any known way except to carry immunoglobulin structural genes of the C57BL/Ka allotype. In this respect, ICR CB-17 mice were defined as allotypically homozygous according to the Mendelian inheritance of mouse allotype markers. The homozygosity of these mice was challenged, however, when in certain instances immunoglobulins of the BALB/c allotype appeared in the serum of some ICR CB-17 mice. The appearance of this hidden allotype was usually transient and only associated with immunoglobulins of the IgG (IgG2a) class. The implications of these findings for the inheritance and expression of immunoglobulin structural genes are discussed.

Submitted on September 28, 1973


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