The Journal of Experimental Medicine
VeriKine-HS Human IFN-Beta
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The Journal of Experimental Medicine, Vol 139, 367-379, Copyright © 1974 by The Rockefeller University Press

ARTICLE

HUMORAL IMMUNOSTIMULATION : I. INCREASED UPTAKE OF [125I]IODODEOXYURIDINE AND [3H]THYMIDINE INTO TNP-CELLS TREATED WITH ANTI-TNP ANTIBODY



William T. Shearer 1, Gordon W. Philpott 1, and Charles W. Parker 1

1 From the Departments of Pediatrics, Surgery, and Medicine, Washington University School of Medicine, St. Louis, Missouri 63110

Interaction of microgram quantities of highly purified rabbit anti-TNP antibodies with TNP-substituted HeLa, HEp-2, and L cells caused an intense stimulation of radioactive nucleoside ([125I]UdR and [3H]TdR) uptake which was maximal 24–72 h after exposure of cells to antibody. The stimulation of nucleoside uptake and presumaly DNA synthesis was shown to be immuno logically mediated because unsubstituted cells were not stimulated by anti-TNP antibody, normal rabbit gamma globulin did not stimulate TNP-cells, and a hapten inhibitor, epsi-DNP-lysine, prevented the stimulation of TNP-cells by anti-TNP antibody. These findings demonstrate that interaction of antibody with cell surface antigen can alter cell membrane transport, and possibly can enhance cell growth.

Submitted on October 9, 1973


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