ARTICLE

Gordon D. Ross ¹, Margaret J. Polley ¹, Enrique M. Rabellino ¹, and Howard M. Grey ¹

¹ From the Department of Medicine, Cornell University Medical College, New York 10021, and the National Jewish Hospital and Research Center, Denver, Colorado 80206

In the present study it was shown that normal peripheral lymphocytes have two different complement receptors: one for C3b (the immune adherence receptor) and one for C3b subsequent to its cleavage by C3b inactivator. The two receptors are not cross-reactive and were shown by tests with various antisera to be antigenically distinct. Both the immune adherence receptor and the receptor for C3b inactivator-cleaved C3b were found on normal peripheral lymphocytes and on cultured lymphoblastoid cells. In 15 out of 18 chronic lymphatic leukemia patients, the immune adherence receptor was either partially or completely missing from the peripheral lymphocytes, while the lymphocyte receptor for C3b inactivator-cleaved C3b was retained. Normal erythrocytes, on the other hand, were found to have only the immune adherence receptor. Granulocytes from normal peripheral blood appeared to have only a receptor for C3b and did not have a receptor for C3b inactivator-cleaved C3b.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Rossbacher, J., Shlomchik, M. J. (2003). The B Cell Receptor Itself Can Activate Complement to Provide the Complement Receptor 1/2 Ligand Required to Enhance B Cell Immune Responses In Vivo. JEM 198: 591-602 [Abstract] [Full Text]  
• Krushkal, J., Bat, O., Gigli, I. (2000). Evolutionary Relationships Among Proteins Encoded by the Regulator of Complement Activation Gene Cluster. Mol Biol Evol 17: 1718-1730 [Abstract] [Full Text]  
• FRANK, M. M., SCHREIBER, A. D., ATKINSON, J. P., JAFFE, C. J. (1977). Pathophysiology of Immune Hemolytic Anemia. ANN INTERN MED 87: 210-222 [Abstract]  
• Carapeto, F. J., Winkelmann, R. K., Jordon, R. E. (1976). T and B Lymphocytes in Contact and Atopic Dermatitis. Arch Dermatol 112: 1095-1100 [Abstract]  
• Luckasen, J. R., Sabad, A., Goltz, R. W., Kersey, J. H. (1974). T and B Lymphocytes in Atopic Eczema. Arch Dermatol 110: 375-377 [Abstract]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS